Revisiting the

• Tác giả: Anna Adam, Beatriz Baragaña, Lyn-Marie Birkholtz, Selina Bopp, Alfred W Bronkhorst, Brice Campo, Krypton Carolino, Daisy Chen, Xiu Cheng, Lauren B Coulson, Koen J Dechering, James Duffy, Greg Durst, Lisl Esherick, Madeline A Farringer, David A Fidock, Erika L Flannery, Barbara Forte, Francisco-Javier Gamo, Ian H Gilbert, Michael K Gilson, Karla P Godinez-Macias, Luma Godoy Magalhaes, Daniel E Goldberg, Anil K Gupta, Eva S Istvan, Tiantian Jiang, Krittikorn Kumpornsin, Marcus C S Lee, Tiqing Liu, Karen Lobb, Amanda K Lukens, Kyle J McLean, Case W McNamara, Igor M R Moura, Jacquin C Niles, John Okombo, N Connor Payne, Andrew Plater, Srinivasa P S Rao, Miles G Siegel, Jair L Siqueira-Neto, Bente A Somsen, Robert L Summers, Vandana Thathy, J Lincoln Wallis, Elizabeth A Winzeler, Dyann F Wirth, Rumin Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: England : NPJ drug discovery , 2025
• Bộ sưu tập: NCBI
• ID: 687279

Tóm tắt

Identification of novel drug targets is a key component of modern drug discovery. While antimalarial targets are often identified through the mechanism of action studies on phenotypically derived inhibitors, this method tends to be time- and resource-consuming. The discoverable target space is also constrained by existing compound libraries and phenotypic assay conditions. Leveraging recent advances in protein structure prediction, we systematically assessed the