Physiological Small Airways Dysfunction and the Bronchodilator Response in Adults With Asthma and Its Risk Factors: A Retrospective Analysis.

• Tác giả: Mohammed A Almeshari, Nowaf Y Alobaidi, Prasad Nagakumar, Elizabeth Sapey, James A Stockley, Robert A Stockley, Benjamin Paul Sutton
• Ngôn ngữ: eng
• Ký hiệu phân loại: 155.412 Sensory perception, movement, emotions, physiological drives
• Thông tin xuất bản: New Zealand : Journal of asthma and allergy , 2025
• Bộ sưu tập: NCBI
• ID: 687319

Tóm tắt

 BACKGROUND: Physiological evidence of small airways dysfunction (SAD) is present in some patients with asthma and is associated with poor disease control. It is unclear if this represents a distinct phenotype of asthma or if it is an early manifestation of the disease. The study aimed to evaluate SAD in asthma and its clinical associations. METHODS: A retrospective analysis of routinely collected health data obtained from adults referred for routine spirometric assessment as part of their clinical management. The Maximal Mid-Expiratory Flow (MMEF) z-scores were used to assess the prevalence and association factors for SAD. Pre- and post-bronchodilator data of MMEF and FEV RESULTS: A total of 1094 patients were included. 366 (33.5%) had evidence of SAD of whom 261 (71.3%) also had AO. Current smokers were at an increased risk of having SAD (OR: 2.05
  95% CI: 1.43-2.93). 214 patients had Bronchodilator response (BDR) data with 157 (73.4%) demonstrating BDR for MMEF and 121 (56.5%) for FEV CONCLUSION: SAD is common in asthma and is related to the presence of AO, cigarette smoking and is associated with increased BDR for both FEV