Nedd4L signaling contributes to carbon tetrachloride-induced liver fibrosis in female mice and is associated with enteric dysbacteriosis.

• Tác giả: Yanghui Bi, Bangtao Chen, Cheng Chen, Song He
• Ngôn ngữ: eng
• Ký hiệu phân loại: 631.847 Biological methods of soil nitrification
• Thông tin xuất bản: England : Gastroenterology report , 2025
• Bộ sưu tập: NCBI
• ID: 687362

Tóm tắt

BACKGROUND: Liver fibrosis is characterized by hepatic stellate cell (HSC) activation and collagen overproduction, but its pathogenesis remains largely unknown. This study aimed to uncover the role of neural precursor cell expressed developmentally downregulated 4-like (Nedd4L) signaling in liver fibrosis and its relationship with gut microbiota. METHODS: Intraperitoneal injection of carbon tetrachloride (CCl RESULTS: An approximately 3-fold elevation in CONCLUSION: Hepatic Nedd4L signaling contributes to CCl