Structural analysis and treatment of acute liver injury of polysaccharides from the

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Tác giả: Zhongpeng Ding, Yilin Du, Jing Lei, Senlin Shi, Yu Xia, Beihua Xu, Qianyi Ying, Ningchen Zhang

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Switzerland : Frontiers in pharmacology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 687408

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OBJECTIVE: To investigate the therapeutic effects of the PRAC on acute liver injury and its potential as an ingredient in drugs and nutraceuticals. METHODS: Microwave-assisted extraction technology combined with Box-Behnken model combined with the three kinds of artificial neural networks was used to optimize PRAC extraction process. Characterize the structure and composition of PRAC. In order to prevent PRAC from being degraded by the gastrointestinal environment, PRAC-loaded liposomes were fabricated. The efficacy of PRAC-loaded liposomes was evaluated by three acute liver injury animal models prepared according to different mechanisms. RESULTS: The best yield of PRAC was 4.49%, and the purity reached up to 86.53% by optimizing the microwave parameters using Box-Behnken model combined with the three kinds of artificial neural networks. PRAC was characterized as a galactan having a backbone consisting predominately of →4)-D-Gal CONCLUSION: PRAC is a potential drug for the treatment of acute liver injury.

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