Signs of Hyperinflation and Ventilation Heterogeneity in Individuals With Severe Alpha-1-Antitrypsin Deficiency at the Age of 42.

• Tác giả: Eeva Piitulainen, Georg Rüdiger Schramm, Hanan Tanash, Per Wollmer, Suneela Zaigham
• Ngôn ngữ: eng
• Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a
• Thông tin xuất bản: New Zealand : International journal of chronic obstructive pulmonary disease , 2025
• Bộ sưu tập: NCBI
• ID: 687487

Tóm tắt

BACKGROUND: Severe alpha-1-antitrypsin deficiency (AATD) is a known risk factor for early development of emphysema and COPD. By the Swedish national screening program within the years 1972-74 a cohort of individuals with severe AATD (PiZZ) was identified and regularly followed up. The aim of this study was to investigate alveolar volume (V METHODS: All study participants underwent pulmonary function tests (PFT) including dynamic spirometry and total lung capacity (TLC), residual volume (RV), functional residual capacity (FRC) and alveolar volume (V RESULTS: Fifty-six PiZZ and 66 PiMM individuals participated in the study. The PiZZ individuals had a significantly lower V CONCLUSION: At the age of 42 the PiZZ ever-smokers have signs of hyperinflation and ventilation heterogeneity.