Expression of Proliferating Cell Nuclear Antigen (PCNA) in Nasal Polyp: A Systematic Review and Meta-analysis.

• Tác giả: Alireza Barouh, Zahra Ghorbanniadelavar, Mohammadreza Jalali Nadoushan, Mohammadreza Karimi Nemch, Mohammadhosein Rohani Bastami, Alireza Shadmand, Sina Shahshenas, Seyed Davar Siadat, Masood Soltanipur, Hossein Yarmohammadi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 653.427076 Handwritten systems
• Thông tin xuất bản: India : Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India , 2025
• Bộ sưu tập: NCBI
• ID: 687549

Tóm tắt

UNLABELLED: Nasal polyp (NP) is a pathological benign mass that affects the nasal cavity and paranasal sinuses. This lesion is occasionally associated with chronic rhinosinusitis (CRS), which is named chronic rhinosinusitis with nasal polyps (CRSwNP). Proliferating cell nuclear antigen (PCNA) indicates abnormal cell proliferation which may help assess the nasopharyngeal lesions and upper airway cancers. This study aimed to examine the PCNA expression in NP tissue. This study was conducted under the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A thorough search using relevant keywords was performed on the electronic database to identify studies examining the PCNA expression in NP. Meta-analysis on pooled single group proportion and means of PCNA expression was conducted by the metamean and metaprop functions in R software (version 4.4.0). Quality assessment was done according to the Joanna Briggs Institute (JBI) checklist. Ten articles were included in this study. The PCNA expression in NP was higher than in normal nasal mucosa (NNM), while its expression in NP was lower than in inverted papilloma (IP). The mean percentage of PCNA expression in NP was 15.73% (95%-CI[2.87-28.58]) with considerable heterogeneity ( SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12070-024-05172-y.