Synergistic Effects of a Novel Multifunctional Bionic Scaffold and Electrical Stimulation Promote Bone Tissue Regeneration.

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Tác giả: Huanyan Dai, Bing Han, Xi Li, Peng Liu, Zhiyan Wu, Zhimin Xu, Yingxin Zhang

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Biotechnology and bioengineering , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 687602

Electrical stimulation (ES) can effectively regulate cell behavior and promote bone tissue regeneration, and conductive biomaterials can further enhance this effect by enhancing the conduction of electrical signals between cells. In this study, poly(lactic-co-glycolic acid) (PLGA) and poly(l-lactide)-aniline pentamer triblock copolymer (PAP) were used as raw materials to prepare a conductive bionic scaffold (PLGA/PAP). Subsequently, bone morphogenetic protein 2 mimetic peptide containing a DOPA tag (DBMP2MP) was loaded on the scaffold surface. The prepared scaffold (DBMP2MP@PLGA/PAP) had a porosity of 79.17% and a porous structure similar to that of natural cancellous bone. After PAP was added, the mechanical strength and electrical conductivity of the scaffold were increased to 2.79 ± 0.1 kPa and 1.29 ± 0.023 × 10
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