Improvements in tumor therapy require a combination of strategies where targeted treatment is critical. We developed a new versatile nanoplatform, MA@E, that generates high levels of reactive oxygen species (ROS) with effective photothermal conversions in the removal of tumors. Enhanced stability liposomes were employed as carriers to facilitate the uniform distribution and stable storage of encapsulated gold nanorods (AuNRs) and Mn-MIL-100 metal-organic frameworks, with efficient delivery of MA@E to the cytoplasm. In the targeted phagocytosis of tumor cells, MA@E can effectively deplete the reduced glutathione (GSH) with increased hydroxyl radicals that combine with Mn