Prophylactic central neck dissection in differentiated thyroid cancer: risks and benefits in a population with a high rate of tumor recurrence.

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Tác giả: Gianluca Aimaretti, Paolo Aluffi Valletti, Valeria Dell'era, Massimiliano Garzaro, Paolo Marzullo, Chiara Mele, Loredana Pagano, Melissa Raia, Maria T Samà

Ngôn ngữ: eng

Ký hiệu phân loại: 297.1248 Sources of Islam

Thông tin xuất bản: Italy : Minerva endocrinology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 687733

 BACKGROUND: The role of prophylactic central neck dissection (pCND) in differentiated thyroid cancer (DTC) is still controversial. METHODS: In a cohort of 274 DTC cN0 patients with a high rate of tumor recurrence, who underwent total thyroidectomy with or without pCND, clinical and histopathological features were retrospectively analyzed. RESULTS: In our cohort, no clinical or histopathological features are able to predict the presence of central lymph node metastases (CLNM) at diagnosis, which instead represents the only variable significantly associated with a higher risk of long-term tumor relapse, independently from age, sex, BMI and radioiodine treatment (OR=1.03, 95% CI: 1.002-1.074, P<
 0.05). Moreover, our study demonstrates that pCND does not significantly increase the risk of post-surgical complications. CONCLUSIONS: In our setting, pCND could have a key role in the management of DTC. The risks and benefits of pCND should be evaluated for each population to make the most appropriate therapeutic choice.
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