Defining the exit meta-analysis.

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Tác giả: Jazeel Abdulmajeed, Tawanda Chivese, Suhail A R Doi, Luis Furuya-Kanamori, Lukman Thalib, Chang Xu

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : JBI evidence synthesis , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 688178

INTRODUCTION: In recent decades, clinical research has seen significant advancements, both in the generation and synthesis of evidence through meta-analyses. Despite these methodological advancements, there is a growing concern about the accumulation of repetitive and redundant literature, potentially contributing to research waste. This highlights the necessity for a mechanism to determine when a meta-analysis has conclusively addressed a research question, signaling no further need for additional studies-a concept we term an "exit" meta-analysis. METHODS: We introduced a convergence index, the Doi-Abdulmajeed Trial Stability (DAts) index, and a convergence plot to determine the exit status of a meta-analysis. The performance of DAts was examined through simulation and applied to two real-world meta-analyses. RESULTS: The DAts index and convergence plot demonstrate highly effective discriminative ability across varying study scenarios. This represents the first attempt to define an exit meta-analysis using a quantitative measurement of stability (as opposed to sufficiency) and its corresponding plot. The application to real-world scenarios further validated the utility of DAts and the convergence plot in identifying a conclusive (exit) meta-analysis. CONCLUSION: The new development of DAts and the convergence plot provide a promising tool for investigating the conclusiveness of meta-analyses. By identifying an exit status for meta-analysis, the scientific community may be equipped to make better-informed decisions on the continuation of research on a specific topic, thereby preventing research waste and focusing efforts on areas with unresolved questions.
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