Same-Day Repeatability and 28-Day Reproducibility of Xenon MRI Ventilation in Children With Cystic Fibrosis in a Multi-Site Trial.

 0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Zackary I Cleveland, Sean B Fain, Deborah Froh, Jaime Mata, Joseph W Plummer, Felix Ratjen, David J Roach, Michael J Rock, Giles Santyr, Sanja Stanojevic, Laura L Walkup, Matthew M Willmering, Jason C Woods, Brandon Zanette

Ngôn ngữ: eng

Ký hiệu phân loại: 388.413 Activities and services

Thông tin xuất bản: United States : Journal of magnetic resonance imaging : JMRI , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 688183

BACKGROUND: MRI with xenon-129 gas (Xe MRI) can assess airflow obstruction and heterogeneity in lung diseases. Specifically, Xe MRI may represent a sensitive modality for future therapeutic trials of cystic fibrosis (CF) therapies. The reproducibility of Xe MRI has not yet been assessed in the context of a multi-site study. PURPOSE: To determine the same-day repeatability and 28-day reproducibility of Xe MRI in children with CF. STUDY TYPE: Four-center prospective, longitudinal. POPULATION: Thirty-eight children (18 females, 47%), median interquartile range (IQR) age 12 (9-14) years old, with mild CF (forced expiratory volume in 1 second (FEV FIELD STRENGTH/SEQUENCE: 3-T, two-dimensional (2D) gradient-echo (GRE) sequence. ASSESSMENT: Xe MRI, FEV STATISTICAL TESTS: Inter-site comparisons were conducted using Kruskal-Wallis nonparametric tests with Dunn's multiple-comparisons tests. Differences for individuals were assessed using Wilcoxon matched-pairs tests. Bland-Altman tests were used to evaluate same-day repeatability, 28-day reproducibility, and inter-reader agreement. A P-value ≤0.05 was considered significant. RESULTS: Median FEV DATA CONCLUSION: Xe MRI may offer excellent same-day and short-term reproducibility. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2.
Tạo bộ sưu tập với mã QR

THƯ VIỆN - TRƯỜNG ĐẠI HỌC CÔNG NGHỆ TP.HCM

ĐT: (028) 36225755 | Email: tt.thuvien@hutech.edu.vn

Copyright @2024 THƯ VIỆN HUTECH