METTL3 confers oxaliplatin resistance through the activation of G6PD-enhanced pentose phosphate pathway in hepatocellular carcinoma.

• Tác giả: Jiong Bi, Fengjie Bie, Muyan Cai, Jiewei Chen, Miaomiao Dai, Jinling Duan, Xiaohan Jin, Si Li, Lianghe Lu, Yongrui Lv, Chao Ma, Fengwei Wang, Dan Xie, Shuidan Xu, Jie Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 722.33 *Ancient Palestinian architecture
• Thông tin xuất bản: England : Cell death and differentiation , 2025
• Bộ sưu tập: NCBI
• ID: 688417

Tóm tắt

 Oxaliplatin-based therapeutics is a widely used treatment approach for hepatocellular carcinoma (HCC) patients
  however, drug resistance poses a significant clinical challenge. Epigenetic modifications have been implicated in the development of drug resistance. In our study, employing siRNA library screening, we identified that silencing the m