BACKGROUND: Hyperpolarized PURPOSE: To quantify spatial distribution of STUDY TYPE: Retrospective. SUBJECTS: Four hundred twenty-one subjects (age = 23.1 ± 17.1, female = 230), comprising healthy controls (N = 60) and subjects with obstructive conditions (asthma [N = 25], bronchiolitis obliterans syndrome [BOS, N = 18], cystic fibrosis [CF, N = 90], lymphangioleiomyomatosis [LAM, N = 50]), restrictive conditions (bleomycin-treated cancer survivors [BLEO, N = 14]
fibrotic lung diseases [FLD, N = 92]), bone marrow transplantation (BMT, N = 53), and bronchopulmonary dysplasia (BPD, N = 19). FIELD STRENGTH/SEQUENCE: 3 T, two-dimensional multi-slice gradient echo. ASSESSMENT: Whole-lung mean DDI was extracted from DDI maps
correlated with VDP (percent of pixels <
60% of whole-lung mean signal intensity) and pulmonary function tests (PFTs) including FEV STATISTICAL TESTS: Pearson correlation analysis and Kruskal-Wallis tests. P <
0.0056 for disease groups, P <
0.0125 for categories. RESULTS: DDI was significantly elevated in BMT (8.3 ± 11.5), BOS (30.1 ± 57.5), BPD (16.0 ± 46.8), CF (15.4 ± 27.2), and LAM (12.6 ± 34.2) compared to controls (1.8 ± 3.1). DDI correlated significantly with VDP in all groups (r ≥ 0.56) except BLEO, and with PFTs in CF, FLD, and LAM (r ≥ 0.56). Obstructive groups had significantly higher mean DDI (14.0 ± 32.0) than controls (1.8 ± 3.0) and restrictive groups (4.0 ± 12.0). DDI/VDP was significantly lower in the restrictive group (0.6 ± 0.6) than controls (0.8 ± 0.6) and obstructive group (1.0 ± 1.0). DATA CONCLUSION: DDI may provide insights into the distribution of ventilation defects across diseases. EVIDENCE LEVEL: 3 TECHNICAL EFFICACY: Stage 2.