The Ercc1

• Tác giả: Luise Angelini, William Cho, William W Hauswirth, Tracy K Her, Laura L Johnson, Linda K McLoon, Seok Hong Min, Akilavalli Narasimhan, Laura J Niedernhofer, Ryan D O'Kelly, Paul D Robbins, Heidi Roehrich, Dorota Skowronska-Krawczyk, Caeden Windschitl, Matthew J Yousefzadeh
• Ngôn ngữ: eng
• Ký hiệu phân loại: 261.57 The arts
• Thông tin xuất bản: England : Aging cell , 2025
• Bộ sưu tập: NCBI
• ID: 688751

Tóm tắt

Age-related macular degeneration (AMD) is a major cause of vision loss in older adults. AMD is caused by degeneration in the macula of the retina. The retina is the highest oxygen consuming tissue in our body and is prone to oxidative damage. DNA damage is one hallmark of aging implicated in loss of organ function. Genome instability has been associated with several disorders that result in premature vision loss. We hypothesized that endogenous DNA damage plays a causal role in age-related retinal changes. To address this, we used a genetic model of systemic depletion of expression of the DNA repair enzyme ERCC1-XPF. The neural retina and retinal pigment epithelium (RPE) from Ercc1