BACKGROUND: This study seeks to thoroughly investigate the generation mechanism of the integrated management pathway for comorbidities, as well as its implementation and execution in practical settings. The findings aim to offer insights for the development of an integrated mechanism for comorbidity services. METHOD: The collected raw data was coded and analyzed in depth by utilizing grounded theory as the research methodology, in conjunction with NVivo 14.0 software for qualitative analysis, and by adhering to domestic and international guidelines and consensus on comorbidity management. RESULT: Following the three-level coding process, a total of 49 initial categories, 14 main categories, and 4 core categories (supply-type, demand-type, collaboration-type, and environment-type) were identified. Subsequently, a four-dimensional comprehensive comorbidities management pathway model, referred to as the "Derivative driving force-management pathway-main body network-operation mechanism," was developed. CONCLUSION: The model integrates the four paths of supply-type, demand-type, collaboration-type, and environment-type with the derived dynamics, subject network, and operation mechanism of comorbidities management. This not only enhances the comprehensiveness and continuity of comorbidities management but also establishes clear direction and evaluation indices for future empirical research.