Aliphatic polycarbonates with acid degradable ketal side groups as multi-pH-responsive immunodrug nanocarriers.

• Tác giả: Pol Besenius, Holger Braunschweig, Jessica Erlenbusch, Adrian V Hauck, Patric Komforth, Lutz Nuhn, Krzysztof Radacki, Judith Stickdorn, Simon Van Herck
• Ngôn ngữ: eng
• Ký hiệu phân loại: 661.22 Sulfuric acid
• Thông tin xuất bản: England : Biomaterials science , 2025
• Bộ sưu tập: NCBI
• ID: 688929

Tóm tắt

Pharmacokinetics and biodistribution profiles of active substances are crucial aspects for their safe and successful administration. Since many immunogenic compounds do not meet all requirements for safe and effective administration, well-defined drug nanocarrier systems are necessary with a stimuli-responsive drug-release profile. For this purpose, a novel pH-responsive aliphatic cyclic carbonate is introduced with benzyl ketal side chains and polymerized onto a poly(ethylene glycol) macroinitiator. The resulting block copolymers could be formulated