Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial.

• Tác giả: Sheryl Ann Abdukahil, Rasha Al Anazi, Ahmed Al Arfaj, Nouf Al Ayadhi, Huda Al Ghamdi, Sameera M Al Johani, Ali M Al Khathaami, Saad Al Mohrij, Hatami Al Mubarak, Abdullah Al Mutrafy, Shaher Al Qahtani, Ali Al Qarni, Eman Al Qasim, Hadeel Al Rehaili, Abdulaziz Alajlan, Yousef Alalawi, Abdulaleem Alatassi, Abdulaziz Aldawood, Omar AlDibasi, Hasan M Al-Dorzi, Abdulaziz A Alghamdi, Abdulrahman Alhadab, Fahad Al-Hameed, Ahmad Alharbi, Raed H AlHazme, Mufareh Edah AlKatheri, Abdul Hadi Al-Qahtani, Saad Al-Qahtani, Fawaz K Al-Rabeah, Abdulmohsen Alsaawi, Nahar Alselaim, Turki Alwasaidi, Ali H Alyami, Zeyad Alyousef, Mohammed Alzahrani, Mohammed Alzunitan, Yaseen M Arabi, Razan Babakr, Salih Bin Salih, Angela Caswell, Hani Mustafa, Tariq Nasser, Tagwa Omer, Musharaf Sadat, Nabiha Tashkandi, Ramesh Kumar Vishwakarma, Saleh Zahrani
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.84913 Diseases of nervous system and mental disorders
• Thông tin xuất bản: United States : JAMA , 2025
• Bộ sưu tập: NCBI
• ID: 689085

Tóm tắt

 IMPORTANCE: Sepsis screening is recommended among hospitalized patients but is supported by limited evidence of effectiveness. OBJECTIVE: To evaluate the effect of electronic sepsis screening, compared with no screening, on mortality among hospitalized ward patients. DESIGN, SETTING, AND PARTICIPANTS: In a stepped-wedge, cluster randomized trial at 5 hospitals in Saudi Arabia, 45 wards (clusters) were randomized into 9 sequences, 5 wards each, to have sepsis screening implemented at 2-month periods. The study was conducted between October 1, 2019, and July 31, 2021, with follow-up through October 29, 2021. INTERVENTION: An electronic alert, based on the quick Sequential Organ Failure Assessment score, was implemented in the electronic medical record in a silent mode that was activated to a revealed mode for sepsis screening. MAIN OUTCOMES AND MEASURES: The primary outcome was 90-day in-hospital mortality. There were 11 secondary outcomes, including code blue activation, vasopressor therapy, incident kidney replacement therapy, multidrug-resistant organisms, and Clostridioides difficile. RESULTS: Among 60 055 patients, 29 442 were in the screening group and 30 613 in the no screening group. They had a median age of 59 years (IQR, 39-68), and 30 596 were male (51.0%). Alerts occurred in 4299 of 29 442 patients (14.6%) in the screening group and 5394 of 30 613 (17.6%) in the no screening group. Within 12 hours of the alert, patients in the screening group were more likely to have serum lactate tested (adjusted relative risk [aRR], 1.30
  95% CI, 1.16-1.45) and intravenous fluid ordered (aRR, 2.17
  95% CI, 1.92-2.46) compared with those in the no screening group. In the primary outcome analysis, electronic screening resulted in lower 90-day in-hospital mortality (aRR, 0.85
  95% CI, 0.77-0.93
  P <
  .001). Screening reduced vasopressor therapy and multidrug-resistant organisms but increased code blue activation, incident kidney replacement therapy, and C difficile. CONCLUSIONS AND RELEVANCE: Among hospitalized ward patients, electronic sepsis screening compared with no screening resulted in significantly lower in-hospital 90-day mortality. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04078594.