OBJECTIVE: Heavy goods vehicle drivers face difficult working conditions, promoting unhealthy lifestyle behaviors which are associated with an elevated prevalence of long-term health conditions. METHODS: One hundred nine drivers across the UK completed an online survey investigating differences in lifestyle behaviors between drivers with ( n = 54) and without obesity ( n = 55), including differences on work and nonworkdays using an exploratory data analysis approach. RESULTS: Drivers with obesity (49.6%) perceived more barriers to healthy eating and being active than drivers without obesity. Drivers with obesity reported choosing more unhealthy options as snacks, ate more often at fast-food chains, and fewer fulfilled the physical activity guidelines. Additionally, the two groups differed regarding food and beverage choices on work and nonworkdays. CONCLUSIONS: Heavy goods vehicle drivers with obesity exhibit various dietary and physical activity behaviors associated with overnutrition and poor cardiometabolic health.