BACKGROUND: Cardiac fibrosis, characterized by excessive extracellular matrix (ECM) deposition in the myocardium, is an important target for heart disease treatments. METHODS: To induce myocardial damage, we performed left anterior descending coronary artery ligation. We generated RESULTS: Our study demonstrates that myocardial infarction reduces DNA methylation at the imprinting control region of the maternally imprinted gene CONCLUSIONS: This study demonstrates that