Composite spin probes with adjustable oxygen sensitivity for pulse electron paramagnetic resonance imaging.

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Tác giả: Irene Canavesi, Boris Epel, Raman Khurana, Mrignayani Kotecha, Periannan Kuppusamy, Mark David Pagel, Navin Viswakarma

Ngôn ngữ: eng

Ký hiệu phân loại: 598.8 *Passeriformes (Perching birds)

Thông tin xuất bản: United States : Magnetic resonance in medicine , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 689813

PURPOSE: Solid crystalline spin probes, such as lithium phthalocyanine (LiPc) and lithium octa-n-butoxynaphthalocyanine (LiNc-BuO), allow repeated oxygen measurement using electron paramagnetic resonance (EPR). Due to their short relaxation times, their use for pulse EPR oxygen imaging is limited. In this study, we developed and tested a new class of solid composite spin probes that modified the relaxation rates R METHODS: The composite probes were developed by embedding LiPc or LiNc-BuO with bonewax, beeswax, or petroleum jelly. All experiments were performed using a 25-mT EPR imager, JIVA-25®. A selected composite probe, LiPc-BW5 (LiPc + 5-times bonewax), was tested for its in vivo stability and robustness using oxygen-enhanced EPR oxygen imaging. As another application, a LiPc-BW5-based marker was tested to outline the SCC7 tumor in a C3H mouse. RESULTS: The composite probes showed an increased oxygen measurement range compared with unaltered probes. The in vivo experiments with LiPc-BW5 showed the stability of the probes for repeated oxygen imaging up to 4 weeks of measurements. The in vivo pO CONCLUSIONS: We developed a new class of robust and versatile solid composite probes with adjustable oxygen sensitivity that allows pO
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