Epigenetic modulation rescues neurodevelopmental deficits in Syngap1

• Tác giả: Sourav Banerjee, James P Clement, M Eswaramoorthy, Ila Joshi, Tapas K Kundu, Sushmitha S Purushotham, Neeharika M N Reddy, Akash Kumar Singh, Madavan Vasudevan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 597.959 *Anguinomorphoidea
• Thông tin xuất bản: England : Aging cell , 2025
• Bộ sưu tập: NCBI
• ID: 690097

Tóm tắt

SYNGAP1 is a Ras GTPase-activating protein that plays a crucial role during brain development and in synaptic plasticity. Sporadic heterozygous mutations in SYNGAP1 affect social and emotional behaviour observed in intellectual disability (ID) and autism spectrum disorder (ASD). Although neurophysiological deficits have been extensively studied, the epigenetic landscape of SYNGAP1 mutation-mediated intellectual disability is unexplored. Here, we have found that the p300/CBP specific acetylation marks of histones are significantly repressed in the hippocampus of adolescent Syngap1