The lactate receptor HCAR1 drives the recruitment of immunosuppressive PMN-MDSCs in colorectal cancer.

• Tác giả: Lingyan Cao, Xiaolei Chai, Timothy A Chan, Feixiong Cheng, Charis Eng, Bo Feng, Yuanyuan Fu, J Silvio Gutkind, Jiacheng He, Xiangfei Hu, Dali Li, Dawei Li, Guichao Li, Chuang Liu, Meizhen Liu, Mingyao Liu, Weiqiang Lu, Xueyun Ma, Yanlin Ma, Ruth Nussinov, Weiwei Rui, Eytan Ruppin, Meifu She, Jing Sun, Zhonghui Tian, Yang Wang, Yijie Wang, Jingbo Wu, Huaiyu Yang, Xinyu Yang, Bo Yi, Shuyin Ze, Qiansen Zhang, Yao Zhang, Ying Zhang, Zhen Zhang, Senlin Zhao, Yumiao Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Nature immunology , 2025
• Bộ sưu tập: NCBI
• ID: 690297

Tóm tắt

Most patients with colorectal cancer do not achieve durable clinical benefits from immunotherapy, underscoring the existence of alternative immunosuppressive mechanisms. Here we found that activation of the lactate receptor HCAR1 signaling pathway induced the expression of chemokines CCL2 and CCL7 in colorectal tumor cells, leading to the recruitment of immunosuppressive CCR2