Carriers of Parkinson's disease-linked SNCA Rep1 variant have greater non-motor decline: a 4 year follow up study.

• Tác giả: Wing Lok Au, Nicole S Y Chia, Xinyi Choi, Dede Heng, Shermyn Neo, Adeline S L Ng, Ebonne Y L Ng, Samuel Y E Ng, Seyed Ehsan Saffari, Aarthi Santhanakrishnan, Eng-King Tan, Louis C S Tan, Yi Jayne Tan, Kay Yaw Tay, Zheyu Xu, Yi Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 158.1 Personal improvement and analysis
• Thông tin xuất bản: United States : Aging , 2025
• Bộ sưu tập: NCBI
• ID: 690389

Tóm tắt

Alpha-synuclein gene promoter (SNCA Rep1) polymorphism has been linked to Parkinson's Disease (PD) susceptibility and motor symptom severity, but less is known about its longitudinal relationship with non-motor symptom severity. To address this gap, this is the first longitudinal study over 4 years investigating the relationship between Rep1 allele length and non-motor function amongst 208 early PD patients grouped into long (