Polyoxygenated cyclohexenes from the stems of Uvaria calamistrata.

• Tác giả: Haoxuan Jin, Jiahang Li, Lihang Niu, Chunfeng Xie, Cheng Yang, Qiang Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 546.721 *Oxygen
• Thông tin xuất bản: England : Phytochemistry , 2025
• Bộ sưu tập: NCBI
• ID: 690411

Tóm tắt

Nine previously undescribed polyoxygenated cyclohexenes uvacalols L-T (1-9), together with five known analogues (10-14) were obtained from the stems of Uvaria calamistrata. Their structures were established through spectroscopic data analysis, circular dichroism calculations and single-crystal X-ray diffraction. Uvacalols L-N (1-3) are chlorinated analogues. Some compounds were measured for their anti-inflammatory activities through NO generation inhibition in RAW 264.7 cells. Compound 8 had the best inhibitory activity with an IC