OBJECTIVES: This communication is aimed at outlining the role of the National Register of Biological Agents (NRoBA) in the system of working conditions supervision in Poland. MATERIAL AND METHODS: The paper was prepared based on a review of Polish legislation related to employee health protection, as well as scientific literature and recommendations of expert organizations regarding the intentional use of biological agents. RESULTS: Polish law obliges employers to protect the health and safety of employees occupationally exposed to harmful agents. The State Sanitary Inspection and the State Labor Inspection supervise the employer's fulfillment of these obligations. Occupational exposure to biological agents may result from their intentional use (e.g., in the biotechnology industry or a scientific laboratory) or be related to their unintentional presence (e.g., in healthcare, sewage treatment plants, municipal waste management plants). Making a distinction between these 2 types of exposure is important for employers in relation to their legal obligations. In the case of using harmful biological agents for scientific, industrial or diagnostic purposes, the employer is obliged to notify the State Sanitary Inspection. Such notifications from employers are gathered in the NRoBA. Its aim is to support hygiene supervision over the intentional use of biological agents and to increase the employer's attention to the protection of the health of employees exposed to these agents. The International Labor Organization (ILO) in 2023 published CONCLUSIONS: The NRoBA in its present form has been used in Poland for almost 2 decades. Now it is time for re-digitalization to ensure its full compliance with the ILO recommendations and to use it in epidemiological studies. Int J Occup Med Environ Health. 2025
38(1):91-97.