Design and simulation of biomimetic microfluidic designs to achieve uniform flow and DNA capture for high-throughput multiplexing.

• Tác giả: Jonathan L'Heureux-Hache, Phoebe Li, Enas Osman, Leyla Soleymani
• Ngôn ngữ: eng
• Ký hiệu phân loại: 658.40352 Executive management
• Thông tin xuất bản: England : Lab on a chip , 2025
• Bộ sưu tập: NCBI
• ID: 690708

Tóm tắt

High-throughput multi-analyte point-of-care detection is often constrained by the limited number of analytes that can be effectively monitored. This study introduces bio-inspired microfluidic designs optimized for multi-analyte detection using 38-42 biosensors. Drawing inspiration from the human spinal cord and leaf vein networks, these perfusion-oriented designs ensure uniform flow velocity and consistent molecular capture while maintaining spatial separation to prevent cross-talk.