A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics.

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Tác giả: Maximilian Joesch, Peter Koppensteiner, Florian H Schmidt, Anton Sumser, Olga Symonova, Tomas Vega-Zuniga

Ngôn ngữ: eng

Ký hiệu phân loại: 234.162 Confirmation

Thông tin xuất bản: United States : Nature neuroscience , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 690883

For accurate perception and motor control, an animal must distinguish between sensory experiences elicited by external stimuli and those elicited by its own actions. The diversity of behaviors and their complex influences on the senses make this distinction challenging. Here, we uncover an action-cue hub that coordinates motor commands with visual processing in the brain's first visual relay. We show that the ventral lateral geniculate nucleus (vLGN) acts as a corollary discharge center, integrating visual translational optic flow signals with motor copies from saccades, locomotion and pupil dynamics. The vLGN relays these signals to correct action-specific visual distortions and to refine perception, as shown for the superior colliculus and in a depth-estimation task. Simultaneously, brain-wide vLGN projections drive corrective actions necessary for accurate visuomotor control. Our results reveal an extended corollary discharge architecture that refines early visual transformations and coordinates actions via a distributed hub-and-spoke network to enable visual perception during action.
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