Synthesis and evaluation of a novel bifunctional ligand 3o-C-NETA for Yttrium-90 and Lutetium-177.

• Tác giả: Hyun-Soon Chong, Pengfei Dong, Chi Soo Kang, Siyuan Ren, Inseok Sin, Xiang Sun, Haixing Wang, Hua Xu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 001.44 Support of and incentives for research
• Thông tin xuất bản: England : Bioorganic & medicinal chemistry letters , 2025
• Bộ sưu tập: NCBI
• ID: 690921

Tóm tắt

A bifunctional ligand is an essential component for targeted cancer therapy using cytotoxic radionuclides. We report the synthesis and evaluation of a novel bifunctional ligand, 3o-C-NETA, designed for labeling a bioactive small molecule or an antibody with β-particle emitting radionuclides