Neuraminidase reassortment and oseltamivir resistance in clade 2.3.4.4b A(H5N1) viruses circulating among Canadian poultry, 2024.

• Tác giả: Tamiru N Alkie, Ifeoluwa Ayilara, Nathalie Bastien, Yohannes Berhane, Cassidy N G Erdelyan, Tamiko Hisanaga, Tomy Joseph, Oliver Lung, Lemarie Pama, Sugandha Raj, Charlene Ranadheera, Anthony V Signore
• Ngôn ngữ: eng
• Ký hiệu phân loại: 664.93 Poultry
• Thông tin xuất bản: United States : Emerging microbes & infections , 2025
• Bộ sưu tập: NCBI
• ID: 691053

Tóm tắt

We report the detection of a clade 2.3.4.4b A(H5N1) reassortant virus with a neuraminidase surface protein derived from a North American lineage low-pathogenic avian influenza virus. This virus caused a widespread and ongoing outbreak across 45 poultry farms in British Columbia, Canada. Isolates from 8 farms reveal a mutation in the neuraminidase protein (H275Y) that is exceptionally rare among clade 2.3.4.4b viruses (present in 0.045% of publicly available clade 2.3.4.4b isolates). NA-H275Y is a well-known marker of resistance to the neuraminidase inhibitor oseltamivir. We demonstrate that this substitution maintains its resistance phenotype on the genetic background of H5N1 clade 2.3.4.4b viruses.