Synthesis of selected plant metabolites of icafolin-methyl

• Tác giả: Pascal Janisch, Julia Maletz, Stefan Moczarski, Dmytro Ostrovskyi, Göran Schulz
• Ngôn ngữ: eng
• Ký hiệu phân loại: 378.242 Thesis and dissertation requirements
• Thông tin xuất bản: England : Organic & biomolecular chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 691111

Tóm tắt

A scalable and diastereoselective synthesis of four icafolin-methyl plant metabolites bearing a 4-hydroxy-2-isoxazoline scaffold is described. The key to success was a practical cyclocondensation of 3,5-difluoronitromethane with α-formylbutyrolactone and a multigram-scale Grieco dehydration protocol, performed in continuous flow.