Development of a novel polyelectrolyte complex nanocomposite of modified chitosan and karaya gum for co-delivery of 5-fluorouracil and curcumin for cancer therapy.

• Tác giả: Rakshitha Anjar, Vishalakshi Badalamoole, Rompicherla Narayana Charyulu, Manohar Mahadev
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Journal of materials chemistry. B , 2025
• Bộ sưu tập: NCBI
• ID: 691205

Tóm tắt

Combination chemotherapy is a relatively recent and preferred method for cancer treatment. Sustained delivery of dual drugs can be achieved with a suitable matrix. In the present work, a pH-responsive polyelectrolyte complex (PEC) of trimethylchitosan and carboxymethylkaraya gum containing silver nanoparticles (SNps) has been developed as a matrix material for co-delivery of the drugs, 5-fluorouracil (5-Fu) and curcumin (Cur). The experimental conditions have been optimized for high yield and high swelling of the PEC nanocomposite.