Loss of VSTM2A promotes adipocyte hypertrophy and disrupts metabolic homeostasis.

• Tác giả: Manal Al Dow, William T Festuccia, Yves Gélinas, Gustavo R Gilio, Marilou Hardy, Mathieu Laplante, Venkata S K Manem, Mickael Massicard, Mathieu C Morissette, Mathilde Mouchiroud, Marianne Rochette, Blandine Secco
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Obesity (Silver Spring, Md.) , 2025
• Bộ sưu tập: NCBI
• ID: 691216

Tóm tắt

OBJECTIVE: Adipose tissue expands through hyperplasia and hypertrophy to store excess lipids, a process that is essential for the maintenance of metabolic homeostasis. The mechanisms regulating adipocyte recruitment from progenitors remain unclear. We have previously identified V-set and transmembrane domain-containing protein 2A (VSTM2A) as a factor promoting fat cell development in vitro. Whether VSTM2A impacts adipose tissue and systemic metabolism in vivo is still unknown. METHODS: We generated VSTM2A knockout mice (Vstm2a RESULTS: Vstm2a CONCLUSIONS: VSTM2A is dispensable for adipose tissue formation, but its loss causes adipocyte hypertrophy and impairs glucose and lipid homeostasis. Our study also underscores a critical role of the lysosome in initiating adipogenesis.