Palladium(II)/Lewis acid catalyzed oxidative olefination of 2-benzamidopyridine 1-oxide with acrylates: synthesis of isoindolinones.

• Tác giả: Subhash Chandra Ghosh, Dharmik M Patel, Raj N Patel, Sachinkumar D Patel, Nileshkumar B Rathod, Mahesh A Sonawane, Dinesh G Thakur
• Ngôn ngữ: eng
• Ký hiệu phân loại: 959.3032 *Thailand
• Thông tin xuất bản: England : Organic & biomolecular chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 691264

Tóm tắt

A palladium(II)/Lewis acid-catalyzed C-H olefination of 2-benzamidopyridine 1-oxide with acrylates followed by intramolecular aza-Michael addition for the synthesis of isoindolinones has been developed. The use of a heterobimetallic Pd(II)/Cu(II) catalyst enhances the efficiency of the reaction, enabling the synthesis of a potential anti-sedative agent.