BACKGROUND: Citrus peels are rich in flavonoids with potential sedative-hypnotic effects
however, these effects have not yet been fully explored. We previously demonstrated that, in mice, standardized lime peel supplement (SLPS) induced non-rapid eye movement sleep and shortened sleep latency through GABA PURPOSE AND STUDY DESIGN: This study aimed to evaluate the effects of SLPS in adults experiencing sleep disturbances. The randomized, double-blind, placebo-controlled clinical trial involved 80 subjects who received either SLPS (300 mg/day) or placebo for a 2-week period. RESULTS: SLPS significantly improved polysomnographic outcomes, including a reduction in sleep latency, wake after sleep onset, and total wake time, and enhancement of sleep efficiency, total sleep time, and stage 2 sleep. Daytime sleepiness, assessed via the Epworth Sleepiness Scale, was also decreased by SLPS. CONCLUSION: No serious adverse effects or side effects were reported among participants in the SLPS group during the intervention period. Our findings support SLPS as a potential natural sleep aid for improving sleep in adults with sleep disturbance.