Intestinal crypt microbiota modulates intestinal stem cell turnover and tumorigenesis via indole acetic acid.

• Tác giả: Nick Barker, Haiyue Dang, Panpan Feng, Shyamal Goswami, Tinglei Jiang, Parag Kundu, Yuchen Li, Tianhao Liu, Yingying Liu, Yingfei Ma, Giulia Nigro, Lihua Peng, Philippe Sansonetti, Shuli Xing, Jiahua Yang, Yingnan Yang, Shuning Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 620.11299 Engineering mechanics and materials
• Thông tin xuất bản: England : Nature microbiology , 2025
• Bộ sưu tập: NCBI
• ID: 691386

Tóm tắt

Intestinal crypts harbour a specific microbiota but whether and how these bacteria regulate intestinal stem cells (ISCs) or influence colorectal cancer (CRC) development is unclear. Here we screened crypt-resident bacteria in organoids and found that indole acetic acid (IAA) secreted by Acinetobacter radioresistens inhibits ISC turnover. A. radioresistens inhibited cellular proliferation in tumour slices from CRC patients and inhibited intestinal tumorigenesis and spheroid initiation in APC