BACKGROUND: Recent studies have found that ferroptosis is strongly associated with the development of bronchial asthma (BA). However, the mechanism underlying the role of ferroptosis in asthma remains unclear. Yanghe Pingchuan granules (YPG) have significant curative effect in the clinical treatment of BA. In our previous study, we found that YPG inhibit pyroptosis in the airway smooth muscle cells (ASMCs) of and reducing airway inflammation. Whether ferroptosis participated in the YPG treated BA activity is an interesting project. PURPOSE: The aim of this study was to investigate the protective effects and the related mechanisms of YPG against BA. METHODS: We used ultra high-performance liquid chromatograph (UPLC) to analyze the composition of YPG. Ovalbumin (OVA)-induced BA models were developed in vivo. YPG was administered to rats by gavage and ASMCs were isolated and cultured using α-SMA and CCK8 was used to assess cell viability. Gene editing, m RESULTS: Qualitative analysis revealed seven major components in YPG. Our in vivo and in vitro data confirm that YPG significantly induced ferroptosis in ASMCs. YPG treatment effectively increased the expression of Fe CONCLUSION: We show that YPG may induce ferroptosis of ASMCs in BA rats by activating the METTL3/P53/SLC7A11 signaling pathway, thus alleviating disease symptoms.