Enantioselective Organocatalytic Conjugate Addition of Malonates to β,β-Disubstituted β-Trifluoromethyl Enones under High Pressure.

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Tác giả: Michał P Głowacki, Piotr Kwiatkowski, Alicja J Połosak

Ngôn ngữ: eng

Ký hiệu phân loại: 612.014535 Human physiology

Thông tin xuất bản: United States : Organic letters , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 691636

The first enantioselective Michael addition of malonates to acyclic β,β-disubstituted enones has been developed. Sterically hindered β-trifluoromethyl α,β-unsaturated 2-acyl thiazoles and benzothiazoles were found to be the most reactive groups of enones in the reaction catalyzed by bifunctional tertiary amine-thioureas (2-5 mol %). However, application of hyperbaric conditions (8-10 kbar) was required. The adducts containing quaternary stereogenic centers with a CF
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