Decomposable STING nanoagonist-amplified oncolytic virotherapy through remodeling the immunosuppressive microenvironment of triple-negative breast cancer.

• Tác giả: Bo Chen, Nianyong Chen, Rangrang Fan, Chenqian Feng, Gang Guo, Bo Han, Hui Li, Min Mu, Aiping Tong, Guoqing Wang, Bingwen Zou
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Journal of materials chemistry. B , 2025
• Bộ sưu tập: NCBI
• ID: 691647

Tóm tắt

Oncolytic viruses (OVs) are promising for cancer treatment as they specifically replicate in tumor cells. However, the systemic delivery of OVs still faces the challenges of poor tumor targeting, short circulation periods, and limited lytic efficacy. Herein, an OV-concealed targeting nanoagonist (OV-MnO