The discovery of novel leads and new targets is an important approach to address the issue of fungicide resistance by new fungicide development. The indole skeleton has been widely utilized in agrochemicals due to its unique biological activity. YZK-C22 is a potent pyruvate kinase inhibitor with high antifungal activity. Several novel fungicide leads were developed based on YZK-C22. Inspired by these, the [1,2,4]triazino[4,5-