Precision Synthesis and Antiliver Fibrosis Activity of a Highly Branched Acidic 63-Mer Pectin Polysaccharide.

• Tác giả: Pengjun Cai, Kan Ding, Tianhui Hao, Fei He, Chaoyu Hu, Tiehai Li, Wenjing Ma, Ping Wang, Ruixue Wu, Zhuojia Xu, Farong Ye, Hu Zhou, Wanqi Zhou
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of the American Chemical Society , 2025
• Bộ sưu tập: NCBI
• ID: 691840

Tóm tắt

Natural polysaccharides possess various biological functions and have become increasingly important as drug candidates for biomedical development. However, the accessibility to multiple-branched and large-sized acidic polysaccharides with well-defined structures and the identification of related active glycan domains remain challenging. Here, we report the precision synthesis of a highly branched acidic pectin polysaccharide up to a 63-mer containing 10 different glycosidic linkages from