Development of a Synthetic Route to Vonoprazan via Atom Transfer Radical Cyclization.

• Tác giả: Nobuyoshi Doi, Ryoya Imaizumi, Tatsuya Komori, Shigenobu Nishiguchi, Toru Nishikawa, Ken-Ichi Ojima
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : The Journal of organic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 692030

Tóm tắt

In this Note, a new synthetic route to vonoprazan via atom transfer radical cyclization (ATRC) is described. The pivotal 1,3,5-trisubstituted pyrrole ring of vonoprazan has been accomplished by ATRC, the subsequent aromatization which simultaneously occurred with the introduction of