Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent T

• Tác giả: Hadi Abou-El-Hassan, Omar Albastaki, Michael Aronchik, Leah C Beauchamp, Joshua D Bernstock, Masen L Boucher, Wesley Nogueira Brandao, Oleg Butovsky, Tian Cao, Ana Carolina Durão, Kusha Chopra, Patrick da Silva, Marilia Garcia De Oliveira, Saef Izzy, Megha Kaul, Rajesh Krishnan, Toby Lanser, Joon-Hyuk Lee, Kuan-Jung Lu, Rebekah Mannix, Federico Montini, Thais G Moreira, Gabriel Pasquarelli-do-Nascimento, Francisco J Quintana, Rafael M Rezende, Danielle S LeServe, Howard L Weiner, Taha Yahya
• Ngôn ngữ: eng
• Ký hiệu phân loại: 612.826 Diencephalon and brain stem
• Thông tin xuất bản: United States : Nature neuroscience , 2025
• Bộ sưu tập: NCBI
• ID: 692051

Tóm tắt

Neuroinflammation plays a crucial role in traumatic brain injury (TBI), contributing to both damage and recovery, yet no effective therapy exists to mitigate central nervous system (CNS) injury and promote recovery after TBI. In the present study, we found that nasal administration of an anti-CD3 monoclonal antibody ameliorated CNS damage and behavioral deficits in a mouse model of contusional TBI. Nasal anti-CD3 induced a population of interleukin (IL)-10-producing regulatory T cells (T