Generation of Stereocenters via Single-Carbon-Atom Doping Using

• Tác giả: Hayato Fujimoto, Kazuya Imachi, Rio Nishimura, Teruki Nishioka, Satoshi Ogawa, Mamoru Tobisu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 583.5 *Caryophyllidae
• Thông tin xuất bản: United States : Journal of the American Chemical Society , 2025
• Bộ sưu tập: NCBI
• ID: 692105

Tóm tắt

Atomic carbon remains a challenging species for organic synthesis despite its potential to form four covalent bonds in a single step. Single-carbon-atom doping (SCAD) offers a powerful approach to enhancing molecular complexity in one process without atom loss. However, synthetically viable SCAD reactions capable of generating stereocenters have not been realized. Here, we report an SCAD reaction that creates stereocenters by unlocking the reactivity of (