BACKGROUND: Quercetin (QUE), a natural flavonoid, offered an efficient protection against organism injury. N6-methyladenosine (m PURPOSE: We sought to explore protective roles of QUE in mitigating necroptosis and apoptosis triggered by LPS-induced imbalances in mitochondria dynamic and energy metabolism in broiler livers, with a focus on m STUDY DESIGN/METHODS: We used LPS as a stimulus and treated with QUE to establish this in vivo and in vitro. In addition, we treated LMH cells with siMETTL3 (80 nM) to determine its detailed mechanism. RESULTS: Our findings revealed QUE significantly decreased METTL3 expression, leading to a decrease in PTEN m CONCLUSION: In summary, QUE mitigated necroptosis and apoptosis triggered by LPS-induced disorders of mitochondrial kinetic and metabolic processes in broiler livers through its interaction with METTL3, regulating PTEN m