Metabolic engineering to facilitate anti-tumor immunity.

• Tác giả: Kevin Chen, Rachel Chirayil, Justin Cross, Elisa de Stanchina, Lyric Haughton, Kayvan R Keshari, Sara Nunes-Violante, Justin S A Perry, Kaitlyn Pierpont, David A Scheinberg, Tanya Schild, Craig B Thompson, Patrick Wallisch, Ya-Ting Wang, Yixuan Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Cancer cell , 2025
• Bộ sưu tập: NCBI
• ID: 692237

Tóm tắt

Fructose consumption is elevated in western diets, but its impact on anti-tumor immunity is unclear. Fructose is metabolized in the liver and small intestine, where fructose transporters are highly expressed. Most tumors are unable to drive glycolytic flux using fructose, enriching fructose in the tumor microenvironment (TME). Excess fructose in the TME may be utilized by immune cells to enhance effector functions if engineered to express the fructose-specific transporter GLUT5. Here, we show that GLUT5-expressing CD8