Oromandibular dyskinesia is an abnormal, repetitive, involuntary movement of the jaw, tongue, and lips. We report an interesting image of a 72-year-old woman, who underwent 18F- FDG PET/CT for restaging of treated colon cancer. PET/CT scan shows diffuse uptake in orbicularis oris, muscles of the lips, muscles around the mandible and in the oral cavity, and anterior tongue muscles with no abnormality seen on corresponding CT images. A thorough search into patient history revealed the diagnosis of oromandibular dyskinesia.