Palladium-Catalyzed N-Arylation of NH-Sulfoximines with (Hetero)aryl Chlorides in an Aqueous Micellar Environment.

• Tác giả: Wanzhi Chen, Linjie Yang, Yuanfang Zhong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 572.79 Classes of enzymes named according to specific kind of reaction they catalyze
• Thông tin xuất bản: United States : Organic letters , 2025
• Bộ sưu tập: NCBI
• ID: 692449

Tóm tắt

An efficient Pd-catalyzed N-arylation of sulfoximines with (hetero)aryl chlorides was developed under mild aqueous conditions. This reaction proceeded smoothly with a low loading of the Pd catalyst (down to 0.5 mol %) and was completed rapidly within 30 min. A wide range of (hetero)aryl chlorides and sulfoximines were well tolerated, delivering the corresponding (hetero)aryl sulfoximines in good to excellent yields. The gram-scale reaction and pharmaceutical derivatization demonstrated good practicality.