Agent-based modeling of cellular dynamics in adoptive cell therapy.

• Tác giả: Rafet Başar, Stefano Casarin, Ken Chen, May Daher, Merve Dede, Vakul Mohanty, Katayoun Rezvani, Mayra Shanley, Yujia Wang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 615.8043 Specific therapies and kinds of therapies
• Thông tin xuất bản: United States : bioRxiv : the preprint server for biology , 2025
• Bộ sưu tập: NCBI
• ID: 692519

Tóm tắt

Adoptive cell therapies (ACT) leverage tumor-immune interactions to cure cancer. Despite promising phase I/II clinical trials of chimeric-antigen-receptor natural killer (CAR-NK) cell therapies, molecular mechanisms and cellular properties required to achieve clinical benefits in broad cancer spectra remain underexplored. While