Immobile lipopolysaccharides and outer membrane proteins differentially segregate in growing

• Tác giả: Martin J Booth, Edward A K Cohen, Patrick G Inns, Renata Kaminska, Colin Kleanthous, Sandip Kumar, Valentine Lagage, Gideon Mamou, Stephan Uphoff, Jingyu Wang, Scott Ward
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 692574

Tóm tắt

The outer membrane (OM) of gram-negative bacteria is a robust, impermeable barrier that excludes many classes of antibiotics. Contrary to the classical model of an asymmetric lipid bilayer, recent evidence suggests the OM is predominantly an asymmetric proteolipid membrane (APLM). Outer leaflet lipopolysaccharides (LPS) that surround integral β-barrel outer membrane proteins (OMPs) are shared with other OMPs to form a supramolecular network in which the levels of OMPs approach those of LPS. Some of the most abundant OMPs in the