Providing effective training for surgical nurses is important to prevent venous thromboembolism (VTE). This study was conducted to evaluate the effect of a mobile-supported venous thromboembolism training program on the knowledge and practices of surgical nurses. A total of 147 surgical nurses were given mobile-supported venous thromboembolism training. The data were collected using an Information and Practices Form. It was determined that the nurses' knowledge and practice scores increased significantly over time, from baseline (T0) to immediately after training (T1) and 1 month after training (T2) (P <
.0005). All nurses were satisfied with the mobile-based VTE training. A moderate and positive correlation was found between the satisfaction scores of the nurses and their knowledge and practice scores immediately after training (P <
.05). A weak and positive correlation was found between knowledge and practice scores immediately after training and 1 month later (P <
.05). One month before VTE training, two patients were readmitted to the hospital with postoperative VTE. No patients who were given care by the same nurses were readmitted with postoperative VTE 1 month after training. In conclusion, mobile-supported training provided improvement and ensured the sustainability of nurses' knowledge and practices regarding VTE, was a satisfactory and acceptable training strategy, positively affected patient outcomes, and prevented repeated hospitalizations.